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1

11β-Hydroxysteroid dehydrogenase antisense affects vascular contractile response and glucocorticoid metabolism

Graham W Souness, Andrew S Brem, David J Morris

Journal:

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

2

Volcanic terrain and the possible periglacial formation of “excess ice” at the mid-latitudes of Utopia Planitia, Mars

Soare, R.J., Horgan, B., Conway, S.J., Souness, C., El-Maarry, M.R.

Journal:

Earth and Planetary Science Letters

Year:

2015

Language:

english

File:

PDF, 3.09 MB

english, 2015

3

ChemInform Abstract: Quaternary Substituted PDE4 Inhibitors. Part 1. The Synthesis and in vitro Evaluation of a Novel Series of Oxindoles.

C. HULME, G. B. POLI, F.-C. HUANG, J. E. SOUNESS, S. W. DJURIC

Journal:

Year:

1998

File:

PDF, 35 KB

1998

4

ChemInform Abstract: Quaternary Substituted PDE IV Inhibitors. Part 2. The Synthesis and in vitro Evaluation of a Novel Series of γ-Lactams.

C. HULME, K. MORIARTY, F.-C. HUANG, J. MASON, D. MCGARRY, R. LABAUDINIERE, J. SOUNESS, S. DJURIC

Journal:

Year:

1998

File:

PDF, 38 KB

1998

5

ChemInform Abstract: Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors.

W. HE, F.-C. HUANG, B. HANNEY, J. SOUNESS, B. MILLER, G. LIANG, J. MASON, S. DJURIC

Journal:

Year:

1999

File:

PDF, 31 KB

1999

6

ChemInform Abstract: RPR203494 a Pyrimidine Analogue of the p38 Inhibitor RPR200765A with an Improved in vitro Potency.

Alan J. Collis, Martyn L. Foster, Frank Halley, Christopher Maslen, Iain M. McLay, Kenneth M. Page, E. Jane Redford, John E. Souness, Nicola E. Wilsher

Journal:

Year:

2001

File:

PDF, 32 KB

2001

7

Effect of age and day time on the adenosine modulation of basal and insulin-stimulated glucose transport in rat adipocytes

P. Bush, J.E. Souness, V. Chagoya de Sánchez

Journal:

International Journal of Biochemistry

Year:

1988

Language:

english

File:

PDF, 451 KB

english, 1988

8

Geomorphological characterisation and interpretation of a mid-latitude glacier-like form: Hellas Planitia, Mars

Bryn Hubbard, Ralph E. Milliken, Jeffrey S. Kargel, Ajay Limaye, Colin Souness

Journal:

Year:

2011

Language:

english

File:

PDF, 5.38 MB

english, 2011

9

Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors

John E. Souness, David Aldous, Carol Sargent

Journal:

Immunopharmacology

Year:

2000

Language:

english

File:

PDF, 397 KB

english, 2000

10

RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

Alan J Collis, Martyn L Foster, Frank Halley, Christopher Maslen, Iain M McLay, Kenneth M Page, E.Jane Redford, John E Souness, Nicola E Wilsher

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 130 KB

english, 2001

11

Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles

Christopher Hulme, Gregory B. Poli, Fu-Chih Huang, John E. Souness, Stevan W. Djuric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 330 KB

english, 1998

12

Quaternary substituted PDE IV inhibitors II: The synthesis and in vitro evaluation of a novel series of γ-lactams

Christopher Hulme, Kevin Moriarty, Fu-Chih Huang, Jonathon Mason, Dan McGarry, Richard Labaudiniere, John Souness, Stevan Djuric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 305 KB

english, 1998

13

The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I

Christopher Hulme, Kevin Moriarty, Bruce Miller, Rose Mathew, Mercy Ramanjulu, Paul Cox, John Souness, Ken M. Page, Joanne Uhl, Jeffrey Travis, Fu-chih Huang, Richard Labaudiniere, Stevan W. Djuric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 363 KB

english, 1998

14

2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors

John Regan, Joseph Bruno, Daniel McGarry, Gregory Poli, Barbara Hanney, Shelly Bower, Jeffrey Travis, Dennis Sweeney, Bruce Miller, John Souness, Stevan Djuric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 290 KB

english, 1998

15

Orally active indole N-oxide PDE4 inhibitors

Christopher Hulme, Rose Mathew, Kevin Moriarty, Bruce Miller, Mercy Ramanjulu, Paul Cox, John Souness, Ken M. Page, Joanne Uhl, Jeffrey Travis, Richard Labaudiniere, Fu-chih Huang, Stevan W. Djuric

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 357 KB

english, 1998

16

The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy

Iain M. McLay, Frank Halley, John E. Souness, Jeffrey McKenna, Veronique Benning, Mark Birrell, Brenda Burton, Maria Belvisi, Alan Collis, Alex Constan, Martyn Foster, David Hele, Zaid Jayyosi, Mike K

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 744 KB

english, 2001

17

Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues

Morris, David J, Souness, Graham W, Brem, Andrew S, Oblin, Marie-Edith

Journal:

Kidney International

Year:

2000

Language:

english

File:

PDF, 167 KB

english, 2000

18

Benzofuran based PDE4 inhibitors

D.G McGarry, J.R Regan, F.A Volz, C Hulme, K.J Moriarty, S.W Djuric, J.E Souness, B.E Miller, J.J Travis, D.M Sweeney

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 215 KB

english, 1999

19

Salting and drying of yellowtail (Trachurus mccullochi Nichols)

S. BERHIMPON, R. A. SOUNESS, K. A. BUCKLE, R. A. EDWARDS

Journal:

International Journal of Food Science & Technology

Year:

1990

Language:

english

File:

PDF, 585 KB

english, 1990

20

SALTING BEHAVIOR of YELLOWTAIL (TRACHURUS MCCULLOCHI NICHOLS)

SIEGFRIED BERHIMPON, RICHARD A. SOUNESS, ROBERT H. DRISCOLL, KEN A. BUCKLE, RONALD A. EDWARDS

Journal:

Journal of Food Processing and Preservation

Year:

1991

Language:

english

File:

PDF, 506 KB

english, 1991

21

Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin-2 release from murine splenocytes by interacting with a ‘low-affinity’ phosphodiesterase 4 conformer

John E. Souness, Clare Houghton, Nughat Sardar, Michael T. Withnall

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 375 KB

english, 1997

22

An inventory and population-scale analysis of martian glacier-like forms

Colin Souness, Bryn Hubbard, Ralph E. Milliken, Duncan Quincey

Journal:

Year:

2012

Language:

english

File:

PDF, 2.70 MB

english, 2012

23

Suppression of anti-CD3-induced interleukin-4 and interleukin-5 release from splenocytes of mesocestoides corti-infected BALB/c mice by phosphodiesterase 4 inhibitors

John E Souness, Clare Houghton, Nughat Sardar, Michael T Withnall

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 330 KB

english, 1999

24

Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP Phosphodiesterases

John E Souness, Sudha Rao

Journal:

Cellular Signalling

Year:

1997

Language:

english

File:

PDF, 505 KB

english, 1997

25

Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low-affinity’ phosphodiesterase 4 conformer

John E. Souness, Miriam Griffin, Christopher Maslen, Karen Ebsworth, Lisa C. Scott, Kenneth Pollock, Malcolm N. Palfreyman, Jan-Anders Karlsson

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 2.02 MB

english, 1996

26

A Biochemical and Functional Assessment of Monocyte Phosphodiesterase Activity in Healthy and Asthmatic Subjects

LJ Landells, D Spina, JE Souness, BJ O»Connor, CP Page

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2000

Language:

english

File:

PDF, 124 KB

english, 2000

27

Effect of N6-methyladenosine on fat-cell glucose metabolism: Evidence for two modes of action

John E. Souness, John E. Stouffer, Victoria Chagoya de Sanchez

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 855 KB

english, 1982

28

Characterization of 5′-N ethylcarboxamido[3H]adenosine binding to pig aorta smooth muscle membranes

Baljeet K. Diocee, John E. Souness

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 721 KB

english, 1987

29

Characterization of guinea-pig eosinophil phosphodiesterase activity: Assessment of its involvement in regulating superoxide generation

John E. Souness, Caroline M. Carter, Baljeet K. Diocee, Giles A. Hassall, Lorna J. Wood, Nicholas C. Turner

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 1.04 MB

english, 1991

30

Inhibition of pig aortic smooth muscle cell DNA synthesis by selective type III and type IV cyclic AMP phosphodiesterase inhibitors

John E. Souness, Giles A. Hassall, David P. Parrott

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 1.14 MB

english, 1992

31

Isoprenaline induction of cAMP-phosphodiesterase in guinea-pig macrophages occurs in the presence, but not in the absence, of the phosphodiesterase type IV inhibitor rolipram

Maria Kochetkova, Fiona M.F. Burns, John E. Souness

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 722 KB

english, 1995

32

The stimulation of [1-14C]glucose oxidation in isolated fat cells by N6-methyladenosine: An effect independent of cyclic AMP

John E. Souness, Victoria Chagoya De Sánchez

Journal:

Year:

1981

Language:

english

File:

PDF, 314 KB

english, 1981

33

The effect of N6-phenylisopropyladenosine on the regulation of fat cell hexose transport, glucose oxidation and fatty acid release by insulin and catecholamines

John E. Souness, W.Joseph Thompson, Samuel J. Strada, John E. Stouffer

Journal:

Year:

1983

Language:

english

File:

PDF, 438 KB

english, 1983

34

Effects of solubilization and vanadate/glutathione complex on inhibitor potencies against eosinophil cyclic AMP-specific phosphodiesterase

John E. Souness, Christopher Maslen, Lisa C. Scott

Journal:

Year:

1992

Language:

english

File:

PDF, 445 KB

english, 1992

35

The effects of infusions of ring-a-reduced derivatives of aldosterone on the antinatriuretic and kaliuretic actions of aldosterone

David J. Morris, Graham W. Souness, Nora A. Saccoccio, Marcel Harnik

Journal:

Year:

1989

Language:

english

File:

PDF, 596 KB

english, 1989

36

11-Dehydrocorticosterone in the presence of carbenoxolone is a more potent sodium retainer than corticosterone

Graham W. Souness, David J. Morris

Journal:

Year:

1993

Language:

english

File:

PDF, 589 KB

english, 1993

37

18-substituted steroids. part 18. chemical synthesis and mineralocorticoid activity of 2α- and 2β-hydroxyaldosterone

David N. Kirk, Martin H. Schröder, Syed A. Latif, Graham W. Souness, David J. Morris

Journal:

Year:

1993

Language:

english

File:

PDF, 481 KB

english, 1993

38

Possible endogeneous regulators of steroid inactivating enzymes and glucocorticoid-induced Na+ retention

Syed A. Latif, Luzviminda F. Hartman, Graham W. Souness, David J. Morris

Journal:

Year:

1994

Language:

english

File:

PDF, 537 KB

english, 1994

39

Other physiological considerations of protective mechanisms of mineralocorticoid action

Graham W. Souness, Katherine Myles, David J. Morris

Journal:

Year:

1994

Language:

english

File:

PDF, 595 KB

english, 1994

40

Effect of chenodeoxycholic acid on 11β-hydroxysteroid dehydrogenase in various target tissues

David J Morris, Graham W Souness, Syed A Latif, Matthew P Hardy, Andrew S Brem

Journal:

Year:

2004

Language:

english

File:

PDF, 106 KB

english, 2004

41

A new era for food safety regulation in Australia

Tania Martin, Elizabeth Dean, Brigid Hardy, Tony Johnson, Fiona Jolly, Fiona Matthews, Ian McKay, Richard Souness, Jenny Williams

Journal:

Year:

2003

Language:

english

File:

PDF, 297 KB

english, 2003

42

HACCP in Australian food control

Richard Souness

Journal:

Year:

2000

Language:

english

File:

PDF, 67 KB

english, 2000

43

Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine

John E. Souness, Roman Brazdil, Baljeet K. Diocee, Roy Jordan

Journal:

British Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 1.32 MB

english, 1989

44

The effect of cyclic AMP and cyclic GMP phosphodiesterase inhibitors on the superoxide burst of guinea-pig peritoneal macrophages

Nicholas C. Turner, Lorna J. Wood, Fiona M. Burns, Thomas Gueremy, John E. Souness

Journal:

British Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.52 MB

english, 1993

45

Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone

John E. Souness, Maria E. Villamil, Lisa C. Scott, Adrian Tomkinson, Mark A. Giembycz, David Raeburn

Journal:

British Journal of Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.40 MB

english, 1994

46

Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor

David Raeburn, Stephen L. Underwood, Susan A. Lewis, Valerie R. Woodman, Cliff H. Battram, Adrian Tomkinson, Steven Sharma, Roy Jordan, John E. Souness, Stephen E. Webber, Jan-Anders Karlsson

Journal:

British Journal of Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.82 MB

english, 1994

47

11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta- hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on corticosterone in the ADX rat

Journal:

Year:

1995

Language:

english

File:

PDF, 415 KB

english, 1995

48

Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors

He, Wei, Huang, Fu-Chih, Hanney, Barbara, Souness, John, Miller, Bruce, Liang, Guyan, Mason, Jon, Djuric, Stevan

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 178 KB

english, 1998

49

Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogs

Ashton, Michael J., Cook, David C., Fenton, Garry, Karlsson, Jan-Anders, Palfreyman, Malcolm N., Raeburn, David, Ratcliffe, Andrew J., Souness, John E., Thurairatnam, Suga, Vicker, Nigel

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.01 MB

english, 1994

50

Mechanistic Implications of Persulfenate and Persulfide Binding in the Active Site of Cysteine Dioxygenase

Souness, Richard J., Kleffmann, Torsten, Tchesnokov, Egor P., Wilbanks, Sigurd M., Jameson, Geoffrey B., Jameson, Guy N. L.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.75 MB

english, 2013

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